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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are often characterized as focusing on practical aspects of design, including recruitment and consent, adherence and 프라그마틱 카지노 the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographical regions. This kind of heterogeneity, which is essential for pragmatic trials to be reliable and lessen the chance of bias is also essential. Too much heterogeneity, however, can cause problems with the design of the trial.

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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policymakers to help guide their decisions. They can also be a great method of determining the cause-effect relationship between an intervention and its outcomes. However, they should not be used as a substitute for explanation trials.

The concept of pragmatism is controversial and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove a physiological or clinical hypothesis and pragmatic trials that inform the practice and policy decisions. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the features of a pragmatic study which includes recruitment, design and delivery of the intervention, and follow-up.

There is a growing trend in the number of pragmatic trials published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is a sign that the health science community is becoming more sensitive to the issue of pragmatic thinking. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.