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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically described as focusing on practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and had participants from different geographical regions. This type of heterogeneity, which is essential for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. Too much heterogeneity, however, can cause problems with the design of the trial.

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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually requested by practitioners and policymakers to guide their decisions. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. However, they shouldn't be used as a substitute for explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the practice and 프라그마틱 카지노 policy decision-making. They also suggested a framework known as PRECIS for 프라그마틱 체험 pragmatic trials.2 This tool tried to define the elements of a practical study that includes the recruitment, design, and delivery of the intervention and follow-up.

There is a growing increase in the number of pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatics. However, it is important to note that the majority of these trials were conducted in primary care settings.