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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are typically described as a focus on the practical aspects of designing a study that include recruitment and consent, adherence and 프라그마틱 게임 the use of routinely available equipment.

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Pragmatic is a software development company that provides a variety of casino games on online gambling platforms. Pragmatic's iGaming software is used by top operators as well as casinos that are located in the land. The company offers front-end website design tools, analysis tools and marketing, promotions security, payment systems, customer support and bug-reporting. In addition, the company provides its users a safe environment that features high-quality graphics and gameplay.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and had participants from different geographic areas. This type of heterogeneity that is crucial for pragmatic trials to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity can result in issues with the design of the trial.

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The aim of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. Usually, they are requested by practitioners and policymakers in order to guide their decisions. They also provide a useful method of determining the cause-effect relationship between an intervention and its results. However, they shouldn't be used to substitute for explanatory trials.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic research study which includes recruitment, design, delivery of the intervention, and follow-up.

There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary-care settings.